IgG Antibodies: A Predictor of Crohn's Disease Development
Immunology and Serological Response
This research highlights the distinct glycosylation signature of IgG antibodies, which can serve as an early indicator for the development of Crohn's disease. The study demonstrates a correlation between this unique serum glycosylation pattern and the onset of the condition.
Intranasal Immunization and Antibody Production
Intranasal immunization has been shown to induce the production of anti-PT and anti-FHA IgG antibodies in serum. ELISAs (Enzyme-Linked Immunosorbent Assays) are employed to compare serological responses from various immunization techniques.
Specificity and Cross-Reactivity of Antibodies
Anti-PT antibodies exhibit specificity for B. Pertussis, while anti-FHA, anti-PRN, anti-FIM, and anti-ACT antibodies display less specificity due to cross-reactivity. Researchers have investigated the correlations between antibody titers, including anti-PT IgG and anti-filamentous hemagglutinin FHA IgG.
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